Research on concrete fatigue investigates the long-term behavior under cyclic loading with the aim of increasing the lifespan and reliability of structural components. Mechanical properties such as stiffness, crack propagation, and strength are analyzed across multiple scales—from the microstructure of the cement matrix to the component level. A particular focus is on the integration of sustainable concretes with optimized compositions, for example through alternative binders, recycled aggregates, or additives. These new material systems exhibit altered fatigue behavior, which is examined in detail using multiscale experimental and numerical methods. The goal is to develop high-performance, durable, and resource-efficient concretes that perform reliably even under long-term cyclic loading.